Endocrine Abstracts

Inroduction: Progressive baldness and severe hirsutism associated with granulosa cell tumor of ovaries are rare conditions in women. Reported cases are usually pubertal girls and young women. Here, we report a case of postmenopausal baldness and hirsutism due to granulosa cell tumor of the ovary.Case report: A 62 year-old woman presented with baldness and hirsutism on her face, body and back for 3 years. She had menarche at 14 years and menopause at 52 y...

Introduction: Osteogenesis imperfecta (OI) is a congenital, generalized connective tissue disorder characterized by severe osteoporosis and bone fragility. OI is most commonly caused by mutations in genes encoding the α-1 and α-2 chains of type I collagen or proteins involved in posttranslational modification of type I collagen. Although, no controlled studies are done, bisphosphonates are used for the treatment of OI. I.v. bisphosphonates are reported to be more eff...

Introduction: Adrenocortical carcinoma (ACC) is a rare cancer (estimated incidence, 0.7 to 2.0 cases per 1 million population per year) with a poor prognosis. Even after seemingly complete surgical resection, most patients develop recurrence within 5 years. The 5-year survival rate is <15% among patients with metastatic disease.Methods: We present the results of six patients with adrenocortical carcinoma followed in our clinic....

Introduction: Acromegaly is a disease caused by excessive secretion of GH. The cause of acromegaly is GH secreting pituitary adenoam in 99% of the cases. It is estimated that 5% of pituitary adenomas become invasive and may grow to gigantic sizes (>4 cm in diameter). Here, we present a 31 years old acromegalic woman with a delayed diagnosis of a giant invasive pituiatary adenoma.Case report: A 31-year-old woman admitted to our hospital for oligomenor...

Background: Adrenal incidentalomas are defined as clinically silent adrenal masses >1 cm in size and are detected in up to 10% of patients during imaging procedures performed for unrelated conditions. 17% and 23% of incidentally detected adrenal lesions were reported to be bilateral. The bilateral adrenal tumors include metastasis, lymphoma, neuroblastoma, pheochromocytoma, adenoma and myelolipoma. Non-neoplastic bilateral adrenal masses include infectious processes and he...

Introduction: Malignant struma ovari is a rare ovarian mature teratoma. The diagnosis can be done histopathologically. There are no specific diagnostic findings in terms of imaging, clinical and laboratory. We present two cases of malignant struma ovarii in papillary follicular variant subtypes in this report.Case report: Case 1; The patient was a 44 year old female, she had complaints of pelvic pain and a palpable lower abdominal mass. Pelvic MRI examin...

Introduction: Psoriasis is a chronic, inflammatory and T-cell mediated autoimmune disease of skin. Its prevalence is 2–3%. It may improve due to immunesupressive effects of hypercortisolaemia during the active phase of Cushing’s syndrome (CS) and may exacerbate after treatment. The aim of this study was to investigate association of psoriasis with CS.Methods: We prospectively followed 62 patients who had been diagnosed with CS between 2010 and ...

Objective: Physical features such as central obesity, purple stria, thin skin, moon face and buffalo hump may be observed in Cushing’s syndrome (CS). Psychiatric and psychological disturbances may also be present in addition to the physical problems. The most common mental disturbance is major depression. Mania and anxiety disorders may also be seen. It may be detected both in active period or in remission of CS on account of persistent effect of previous period of hyperc...

Introduction: Cushing’s syndrome (CS) is accompanied by a ten times increased risk of venous thromboembolism and arterial thrombosis. In this study we aimed to analyze frequency of thromboembolism in CS.Methods: We prospectively followed 62 patients who had been diagnosed with CS between 2010 and 2014 in our clinic. Of the patients, 60% had Cushing’s disease (CD) (29 females and eight males) and 40% had ACTH-independent CS (20 females and five ...

Background: Papillary thyroid microcarcinoma (PTMC) is a papillary thyroid cancer (PTC) type with a maximum diameter of ≤ 10 mm. Generally, PTMCs have good prognosis and low mortality risk. However, there are cases of PTMCs showing more biologically aggressive characteristics, such as lymph node (LN) involvement and distant metastasis.Objectives: Reveal the factors affecting the prognosis and aggressiveness of PTMCs.Methods: ...